A First Report of Radioembolization for Hepatic Metastases From Ocular Melanoma

被引：54

作者：

Kennedy, Andrew S. ^{[1
]}

Nutting, Charles ^{[2
]}

Jakobs, Tobias ^{[3
]}

Cianni, Roberto ^{[4
]}

Notarianni, Ermanno ^{[4
]}

Ofer, Amos ^{[5
]}

Beny, Alex ^{[6
]}

Dezarn, William A. ^{[1
]}

机构：

[1] Wake Radiol Oncol, Cary, NC 27518 USA

[2] Swedish Med Ctr, Denver, CO USA

[3] Univ Munich, LMU, Dept Radiol, Munich, Germany

[4] SM Goretti Hosp, Latina, Italy

[5] Rambam Hlth Care Campus, Intervent Radiol, Haifa, Israel

[6] Rambam Hlth Care Campus, Med Oncol, Haifa, Israel

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 06期

关键词：

Yttrium-90; Microsphere; Liver; Choroidal; Melanoma; Metastases; Uveal; Hepatic; Brachytherapy; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; SECONDARY LIVER MALIGNANCIES; ART BRACHYTHERAPY TREATMENT; COMS RANDOMIZED-TRIAL; INTRAHEPATIC YTTRIUM-90 MICROSPHERES; LARGE CHOROIDAL MELANOMA; UVEAL MELANOMA; Y-90; MICROSPHERES; INTRAOCULAR MELANOMA; POLYVINYL SPONGE;

D O I：

10.1080/07357900802620893

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Ocular melanoma (OM) metastasizes to the liver and is rapidly fatal despite aggressive therapy. Yttrium-90 microspheres (radioembolization) delivered via the hepatic artery is an established and effective approach for primary and metastatic hepatic tumors, although 90Y use in OM has not been reported previously. Methods: A retrospective review was performed for all patients with OM who received radioembolization at 5 centers. Results: 11 patients received 12 treatments with a median activity of 1.55 GBq delivered per treatment. Toxicity was minimal, with PET/CT at 3 months posttreatment showing a response in all patients; 1 patient had a complete response. Conclusions: Radioembolization can control hepatic metastases of OM with very few side effects.

引用

页码：682 / 690

页数：9

共 60 条

[1] Phase I/II randomized trial of intrahepatic arterial infusion chemotherapy with cisplatin and chemoembolization with cisplatin and polyvinyl sponge in patients with ocular melanoma metastatic to the liver [J].