Rat Models for Bariatric Surgery and Surgery for Type 2 Diabetes Mellitus

被引：16

作者：

Mistry, Sheetal Bharat

Omana, Juan J. ^{[1
]}

Kini, Subhash ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Surg, New York, NY 10029 USA

来源：

OBESITY SURGERY | 2009年 / 19卷 / 05期

关键词：

Rat models; Bariatric surgery; Type 2 diabetes mellitus; Obesity; Insulin resistance; Hyperglycemia; Weight loss; Zucker diabetic fatty (ZDF); Spontaneously hypertensive rat/National Institute of Health corpulent (SHR/N-cp); James C. Russell/LA corpulent (JCR/LA-cp); Otsuka Long-Evans Tokushima Fatty (OLETF); Goto-Kakizaki (GK); Cohen rat; Torri rat; Wistar rat; Sprague-Dawley rat; Zucker fatty (ZF); DUODENAL-JEJUNAL EXCLUSION; NONOBESE ANIMAL-MODEL; DIET-INDUCED OBESITY; TOKUSHIMA FATTY RAT; BETA-CELL FUNCTION; Y GASTRIC BYPASS; ILEAL TRANSPOSITION; GLUCOSE-METABOLISM; WEIGHT-LOSS; GK RAT;

D O I：

10.1007/s11695-009-9811-0

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Type 2 diabetes mellitus being one of the most prevalent diseases in the world has led to a variety of research using animal models. This review focuses on various rat models to study the effect that surgical procedures have on type 2 diabetes mellitus and obesity. Rat models can be classified as Obese Diabetic, Non-Obese Diabetic, Obese Non-Diabetic, and Non-Obese Non-Diabetic. Here, we have discussed the particular characteristics of each rat so that it can provide the appropriate model to study different pathological processes involve in type 2 Diabetes and obesity.

引用

页码：655 / 660

页数：6

共 50 条

[1] ATHEROGENESIS IN 2 STRAINS OF OBESE RATS - THE FATTY ZUCKER AND LA/N-CORPULENT [J].