The Increasing Complexity of the Cancer Stem Cell Paradigm

被引：540

作者：

Rosen, Jeffrey M. ^{[1
]}

Jordan, Craig T. ^{[2
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Univ Rochester, Sch Med, James P Wilmot Canc Ctr, Rochester, NY 14642 USA

来源：

SCIENCE | 2009年 / 324卷 / 5935期

关键词：

ACUTE MYELOID-LEUKEMIA; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-INITIATING CELLS; BREAST-CANCER; PROGENITOR CELLS; IDENTIFICATION; PROGRESSION; RESISTANCE; GROWTH; MODEL;

D O I：

10.1126/science.1171837

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The investigation and study of cancer stem cells (CSCs) have received enormous attention over the past 5 to 10 years but remain topics of considerable controversy. Opinions about the validity of the CSC hypothesis, the biological properties of CSCs, and the relevance of CSCs to cancer therapy differ widely. In the following commentary, we discuss the nature of the debate, the parameters by which CSCs can or cannot be defined, and the identification of new potential therapeutic targets elucidated by considering cancer as a problem in stem cell biology.

引用

页码：1670 / 1673

页数：4

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