Radical additions of xanthates to vinyl epoxides and related derivatives: A powerful tool for the modular creation of quaternary centers

被引：43

作者：

Charrier, Nicolas ^{[1
]}

Gravestock, David ^{[1
]}

Zard, Samir Z. ^{[1
]}

机构：

[1] Ecole Polytech, Dept Chim, CNRS, UMR 7652,Lab Synth Organ Associe, F-91128 Palaiseau, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 39期

关键词：

allylation; allylic alcohols; radical reactions; vinyl epoxides; xanthates;

D O I：

10.1002/anie.200601567

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An open relationship: The triethylborane/O2-mediated addition of xanthates to vinyl epoxides and derivatives represents an efficient process to form carbon-carbon bonds. Complex structures can be rapidly assembled in a modular, convergent manner, under mild conditions, using readily available reagents (see scheme, Bn = benzyl). The formation of quaternary centers proved especially facile. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6520 / 6523

页数：4

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