A stem cell molecular signature

被引：1106

作者：

Ivanova, NB ^{[1
]}

Dimos, JT ^{[1
]}

Schaniel, C ^{[1
]}

Hackney, JA ^{[1
]}

Moore, KA ^{[1
]}

Lemischka, IR ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

SCIENCE | 2002年 / 298卷 / 5593期

关键词：

D O I：

10.1126/science.1073823

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which de ne key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

引用

页码：601 / 604

页数：4

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