Mechanisms of hepatoprotection by nitric oxide

被引：44

作者：

Wang, YN ^{[1
]}

Vodovotz, Y ^{[1
]}

Kim, PKM ^{[1
]}

Zamora, R ^{[1
]}

Billiar, TR ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA

来源：

NITRIC OXIDE: NOVEL ACTIONS, DELETERIOUS EFFECTS AND CLINICAL POTENTIAL | 2002年 / 962卷

关键词：

D O I：

10.1111/j.1749-6632.2002.tb04085.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitric oxide (NO) exerts numerous antiapoptotic effects on hepatocytes in settings of inflammation and tissue damage. These actions of NO are modulated by a variety of mechanisms under both physiologic and pathologic conditions. Nitric oxide inhibits cell death or apoptosis by modulation of heat shock proteins, S-nitrosylation of caspases at their catalytic site cysteine residue, triggering of the cGMP pathway, and prevention of mitochondrial dysfunction. Our preliminary studies also suggest that NO can modulate apoptosis-related genes in a manner consistent with an antiapoptotic effect. This review focuses on these molecular mechanisms of cytoprotection by NO.

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收藏

页码：415 / 422

页数：8

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