Lipopolysaccharides of a Campylobacter coli isolate from a patient with Guillain-Barre syndrome display ganglioside mimicry

被引：23

作者：

Bersudsky, M

Rosenberg, P

Rudensky, B

Wirguin, I ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Neurol, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Goldman Fac Hlth Sci, IL-84105 Beer Sheva, Israel

[3] Shaare Zedek Med Ctr, Dept Neurol, Jerusalem, Israel

[4] Shaare Zedek Med Ctr, Dept Clin Microbiol, Jerusalem, Israel

来源：

NEUROMUSCULAR DISORDERS | 2000年 / 10卷 / 03期

关键词：

lipopolysaccharides (LPS); Campylobacter coli; Guillain-Barre syndrome; ganglioside antibodies; molecular mimicry;

D O I：

10.1016/S0960-8966(99)00106-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Campylobacter coli was isolated from a patient with severe, axonal type Guillain-Barre syndrome (GBS). The patient's serum was tested by ELISA for glycolipid antibodies and showed a high titer of IgG antibodies to asialo-GM1 (GA1) and GD3. Campylobacter coli lipopolysaccharide (LPS) was extracted and analyzed by ELISA, immunoblot binding and blocking studies, and found to avidly bind cholera toxin and peanut agglutinin. The LPS from the patient's isolate also induced anti-GA1 antibodies in a rat model. These findings suggest that the LPS from this bacterial isolate contains a ganglioside-like epitope. which most likely resembles GA1. Thus, it appears that ganglioside cross-reactivity is not unique to Campylobacter jejuni and seems to occur in all bacterial isolates from GBS cases so far analyzed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：182 / 186

页数：5

共 17 条

[1] LIPOPOLYSACCHARIDES FROM CAMPYLOBACTER-JEJUNI ASSOCIATED WITH GUILLAIN-BARRE-SYNDROME PATIENTS MIMIC HUMAN GANGLIOSIDES IN STRUCTURE [J].