Impact, diagnosis and treatment of restless legs syndrome (RLS) in a primary care population: the REST (RLS epidemiology, symptoms, and treatment) primary care study

被引:464
作者
Hening, W
Walters, AS
Allen, RP
Montplaisir, J
Myers, A
Ferini-Strambi, L
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08903 USA
[2] JFK Med Ctr, New Jersey Neurosci Inst, Edison, NJ USA
[3] Seton Hall Univ, Sch Grad Med Educ, S Orange, NJ USA
[4] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA
[5] Univ Montreal, Dept Psychiat & Neurosci, Montreal, PQ, Canada
[6] Premark Serv, Crawley, England
[7] Univ Vita Salute, Dept Neurosci, Milan, Italy
关键词
restless legs syndrome; quality of life; primary care; sleep disturbance; prevalence; insomnia;
D O I
10.1016/j.sleep.2004.03.006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objectives: To assess the frequency, impact, and medical response to the restless legs syndrome (RLS) in a large multi-national primary care population. Method: Questionnaire surveys of matched patients and primary care physicians (PCPs) in five modern industrialized western Countries. Results: An RLS screening questionnaire was completed by 23,052 patients: 2223 (9.6%) reported weekly RLS symptoms; 1557 of these patients had medical follow-up questionnaires completed both by themselves and by their physician. An RLS sufferer subgroup (n = 551) likely warranting treatment was defined as reporting at least twice weekly symptoms with appreciable negative impact on quality of life. A total of 88.4% of RLS sufferers reported at least one sleep-related symptom. Most reported impaired sleep consistent with a diagnosis of insomnia. Out of 551 sufferers. 357 (64.8%) reported consulting a physician about their RLS symptoms, but only 46 of these 357 (12.9%) reported having been given a diagnosis. PCPs reported that 209 (37.9%) RLS sufferers consulted them about RLS symptoms, but only 52 (24.9%) were given an RLS diagnosis. In most countries, sufferers, regardless of diagnosis, were prescribed therapies not known to be effective in RLS. Conclusions: RLS significantly impairs patients' lives, often by severely disrupting sleep. The marked under-diagnosis and inappropriate treatment of RLS indicates that PCPs need better education about this condition. Recognizing how often disrupted sleep results from RLS should improve diagnosis. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:237 / 246
页数:10
相关论文
共 26 条
[1]   Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology - A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health [J].
Allen, RP ;
Picchietti, D ;
Hening, WA ;
Trenkwalder, C ;
Walters, AS ;
Montplaisi, J .
SLEEP MEDICINE, 2003, 4 (02) :101-119
[2]   Restless legs syndrome - A review of clinical and pathophysiologic features [J].
Allen, RP ;
Earley, CJ .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2001, 18 (02) :128-147
[3]   Augmentation of the restless legs syndrome with carbidopa/levodopa [J].
Allen, RP ;
Earley, CJ .
SLEEP, 1996, 19 (03) :205-213
[4]  
Allen RP, 2003, SLEEP, V26, pA341
[5]  
[Anonymous], ANIMAE BRUTORUM
[6]   Restless legs syndrome in 218 patients: associated disorders [J].
Banno, Katsuhisa ;
Delaive, Kenneth ;
Walld, Randy ;
Kryger, Meir H. .
SLEEP MEDICINE, 2000, 1 (03) :221-229
[7]   Practice parameters for the treatment of Restless Legs Syndrome and periodic limb movement disorder [J].
Chesson, AL ;
Wise, M ;
Davila, D ;
Johnson, S ;
Littner, M ;
Anderson, WM ;
Hartse, K ;
Rafecas, J .
SLEEP, 1999, 22 (07) :961-968
[8]  
Ekbom K.A., 1945, Acta Medicorum Scandanivica, V158, P1
[9]  
Garcia-Borreguero Diego, 2003, Neurology, V60, pA11
[10]   Circadian rhythm of motor restlessness and sensory symptoms in the idiopathic Restless Legs Syndrome [J].
Hening, WA ;
Walters, AS ;
Wagner, M ;
Rosen, R ;
Chen, V ;
Kim, S ;
Shah, M ;
Thai, O .
SLEEP, 1999, 22 (07) :901-912