Monosomy 7 and 7q-associated with myeloid malignancy

被引:47
作者
Johnson, E [1 ]
Cotter, FE [1 ]
机构
[1] INST CHILD HLTH,MOL HAEMATOL UNIT,LONDON WC1N 1EH,ENGLAND
关键词
D O I
10.1016/S0268-960X(97)90006-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An association between the complete or partial loss of chromosome 7 and preleukaemic myelodysplasia or acute myeloid leukaemia has been recognized from the early days of tumour cytogenetic analysis. Detection of such abnormalities usually heralds a poor prognosis. The loss of DNA on chromosome 7 has led to speculation that tumour-suppressor genes may play a significant role in this form of leukaemogenesis, although it may be part of a multistep process. A further association with leukaemia secondary to carcinogen exposure including previous chemotherapy or a number of congenital anaemias has increased the interest in discovering the gene or genes on chromosome 7. Banded chromosome analysis has suggested that there are two broad critical regions on the long arm of chromosome 7 at bands 7q22 and 7q34-q36 that may contain the relevant genes. Initial molecular analysis has confirmed these to regions to be of significance. The advent of fluorescence in-situ hybridization techniques has facilitated some definition of the 7q22. region, with identification of candidate genes for further functional analysis. It is becoming clear that there will be more than one gene on chromosome 7 involved in the leukaemic process and with the definition of these genes it may be possible to look for associations with different phenotypes and prognosis. As for the reason for chromosome 7 showing a particular predisposition to total or partial loss we may speculate that the DNA sequence and structure may confer a 'fragility' on the chromosome. A greater understanding of the DNA structure of the long arm may provide real insight into the mechanisms of leukaemia. We would like to speculate in the ion term that this could lead to the ability to screen for leukaemia susceptibility and avoidance of 'inducers' in those at risk.
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页码:46 / 55
页数:10
相关论文
共 129 条
[1]   CLONALITY OF CELL-POPULATIONS IN REFRACTORY-ANEMIA USING COMBINED APPROACH OF GENE LOSS AND X-LINKED RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM METHYLATION ANALYSES [J].
ABRAHAMSON, G ;
BOULTWOOD, J ;
MADDEN, J ;
KELLY, S ;
OSCIER, DG ;
RACK, K ;
BUCKLE, VJ ;
WAINSCOAT, JS .
BRITISH JOURNAL OF HAEMATOLOGY, 1991, 79 (04) :550-555
[2]   COMPARISON OF CYTOGENETIC AND RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSES FOR THE DETECTION OF LOSS OF CHROMOSOME MATERIAL IN CLONAL HEMATOPOIETIC DISORDERS [J].
ABRAHAMSON, GM ;
RACK, K ;
OSCIER, DG ;
FITCHETT, M ;
BUCKLE, VJ ;
WAINSCOAT, JS .
AMERICAN JOURNAL OF HEMATOLOGY, 1993, 42 (02) :171-176
[3]  
[Anonymous], CLIN RES
[4]  
[Anonymous], 1984, CANC GENET CYTOGENET, V11, P249
[5]   ALLOGENEIC MARROW TRANSPLANTATION IN THE TREATMENT OF PRELEUKEMIA [J].
APPELBAUM, FR ;
STORB, R ;
RAMBERG, RE ;
SHULMAN, HM ;
BUCKNER, CD ;
CLIFT, RA ;
DEEG, HJ ;
FEFER, A ;
SANDERS, J ;
STEWART, P ;
SULLIVAN, K ;
WITHERSPOON, R ;
THOMAS, ED .
ANNALS OF INTERNAL MEDICINE, 1984, 100 (05) :689-693
[6]  
APPELBAUM FR, 1987, BLOOD, V69, P92
[7]   LEUKEMIA AND PRELEUKEMIA IN FANCONI ANEMIA PATIENTS - A REVIEW OF THE LITERATURE AND REPORT OF THE INTERNATIONAL FANCONI ANEMIA REGISTRY [J].
AUERBACH, AD ;
ALLEN, RG .
CANCER GENETICS AND CYTOGENETICS, 1991, 51 (01) :1-12
[8]   NEUROFIBROMATOSIS AND CHILDHOOD LEUKEMIA [J].
BADER, JL ;
MILLER, RW .
JOURNAL OF PEDIATRICS, 1978, 92 (06) :925-929
[9]  
BARANGER L, 1990, LEUKEMIA, V4, P345
[10]  
BAURMANN H, 1993, LEUKEMIA, V7, P384