Redundancy, insult-specific sensors and thresholds: unlocking the S-phase checkpoint response

被引：29

作者：

Cobb, JA

Shimada, K

Gasser, SM

机构：

[1] Univ Geneva, Dept Biol Mol, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, NCCR Frontiers Genet, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.gde.2004.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

DNA damage that is not properly repaired during genomic replication is a major source of gross chromosomal rearrangements and sequence loss during cell proliferation. In higher eukaryotes such mutations increase the risk of cancer. Eukaryotic cells have multiple checkpoint responses activated by DNA damage and stalled replication forks. We focus here on fork-associated events that activate and respond to S-phase checkpoint kinases.

引用

收藏

页码：292 / 300

页数：9

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