Regulation of gene expression by neural signals

Regulation of gene expression by extracellular signals is a ubiquitous biological mechanism controlling cell proliferation, differentiation, homeostasis, and adaptation to the environment. This article will focus on one set of issues within the broad topic of regulated gene expression: mechanisms by which neurotransmitters and neural activity regulate genes within the mature nervous system. The regulatory actions of growth factors, cytokines, and other types of extracellular signals are complex matters deserving separate review. This article proceeds from a basic overview of transcriptional regulation to a more specific discussion of the actions of two families of transcriptional regulators, the CREB family and the AP-1 family. These families of proteins are discussed because they play a central role in the regulation of gene expression by neurotransmitters and also because they exemplify many general principles of extracellular signal-regulated gene expression.