Synthesis of a novel 14-membered highly constrained cyclic peptidic scaffold

被引：4

作者：

Arnusch, CJ ^{[1
]}

Pieters, RJ ^{[1
]}

机构：

[1] Univ Utrecht, Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 21期

关键词：

S(N)AR reaction; cyclic peptide; Bi-aryl ether;

D O I：

10.1016/j.tetlet.2004.03.131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and NMR analysis of a novel highly constrained scaffold is described. The 14-membered macrocyclic ring structure was inspired by many medicinally relevant natural products that also contain the bi-aryl ether moiety. The synthesis required only commercially available starting materials and involved a base mediated SNAr cyclization. A conformational search,,vas performed, which indicated a strong preference for a single conformation, which was consistent with observed ROE signals by NMR. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4153 / 4156

页数：4

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