Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents

被引：29

作者：

Cotarelo, M

Catalán, P ^{[1
]}

Sánchez-Carrillo, C

Menasalvas, A

Cercenado, E

Tenorio, A

Bouza, E

机构：

[1] Univ Gregorio Maranon, Gen Hosp, Serv Microbiol Clin & Enfermedades Infect VIH, Madrid 28007, Spain

[2] Ctr Nacl Microbiol Virol & Immunol Sanitarias, Inst Salud Carlos III, Madrid, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 44卷 / 05期

关键词：

D O I：

10.1093/jac/44.5.705

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We compare a rapid dilution method for the determination of antiviral susceptibility of herpes simplex virus (HSV) with the plaque reduction assay, A total of 84 HSV clinical isolates were studied by both methods to detect in-vitro resistance to acyclovir and foscarnet, The rapid method showed for the detection of HSV isolates resistant to acyclovir and foscarnet, a sensitivity of 96.8% and 100% and specificity of 100% and 100%, respectively. This method provides an easy and accurate screening procedure for the susceptibility testing of HSV to antiviral agents.

引用

页码：705 / 708

页数：4

共 9 条

[1]

Arvin Ann M., 1995, P876

[2] RESISTANCE OF HERPESVIRUSES TO ANTIVIRAL DRUGS [J].