Regulating actin dynamics at membranes: A focus on dynamin

被引：119

作者：

Schafer, DA ^{[1
]}

机构：

[1] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA

来源：

TRAFFIC | 2004年 / 5卷 / 07期

关键词：

actin dynamics; dynamin; endocytosis; exocytosis;

D O I：

10.1111/j.1600-0854.2004.00199.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dynamin, the large guanosine triphosphatase, is generally considered to have a key role in deforming membranes to create tubules or vesicles. Dynamin, particularly dynamin2 isoforms, also are localized with actin filaments, often at locations where cellular membranes undergo remodeling. Perturbing dynamin function interferes with endocytic traffic and actin function. Thus, dynamin may regulate actin filaments coordinately with its activities that remodel membranes. This review will highlight recent observations that provide clues to mechanisms whereby dynamin might coordinate membrane remodeling and actin filament dynamics during endocytic traffic, cell morphogenesis and cell migration.

引用

页码：463 / 469

页数：7

共 56 条

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