Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma

被引:143
作者
Molin, D
Edström, A
Glimelius, I
Glimelius, B
Nilsson, G
Sundström, C
Enblad, G
机构
[1] Uppsala Univ, Dept Oncol Radiol & Clin Immunol, Uppsala, Sweden
[2] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, Uppsala, Sweden
关键词
Hodgkin's lymphoma; mast cells; prognosis; histology; bystander cells;
D O I
10.1046/j.1365-2141.2002.03768.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hodgkin's lymphoma (HL) is characterized by a few Hodgkin, Reed-Sternberg cells (HRS) surrounded by benign cells. We recently reported that mast cells were the predominant CD30L-positive cells in HL tumours, and that they activate HRS in vitro through CD30L-CD30 interaction. Here, we investigated the clinical importance of mast cell infiltration in the tumours of 123 patients. Tumour specimens were stained with a mast-cell-specific antibody that detects tryptase. Mast cells were detected in virtually every case and increasing numbers of mast cells correlated to nodular sclerosis histology (P = 0.008). Patients with higher mast cell infiltration had a worse relapse-free survival (P = 0.01).
引用
收藏
页码:122 / 124
页数:3
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