Prevalence of mutations associated with higher levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India

被引：34

作者：

Ahmed, Anwar

Lumb, Vanshika

Das, Manoj K.

Dev, Vas

Wajihullah

Sharma, Yagya D. ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India

[2] Natl Inst Malaria Res, Delhi 110054, India

[3] Aligarh Muslim Univ, Dept Zool, Aligarh 202002, Uttar Pradesh, India

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 11期

关键词：

D O I：

10.1128/AAC.00732-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To assess sulfadoxine and pyrimethamine resistance (SPR), we describe here the dihydropteroate synthetase (DHPS) mutations among the Plasmodium falciparum isolates in which dihydrofolate reductase (DHFR) mutations had recently been described by us (A. Ahmed, M. K. Das, V. Dev, M. A. Saifi, Wajihullah, and Y.D. Sharma, Antimicrob. Agents Chemother. 50:1546-1549, 2006). A majority of isolates from Car Nicobar island showed double DHPS mutations, whereas a majority of isolates from Uttar Pradesh (U.P.) and Assam contained the wild-type DHPS. Based on DHFR-DHPS mutations, the expected level of SPR was lowest in U.P., higher in Assam, and highest in Car Nicobar, suggesting that a region-wise drug policy is needed in India.

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页码：3934 / 3938

页数：5

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