The CTC-Chip An Exciting New Tool to Detect Circulating Tumor Cells in Lung Cancer Patients

被引：156

作者：

Sequist, Lecia V. ^{[1
]}

Nagrath, Sunitha ^{[2
]}

Toner, Mehmet ^{[2
]}

Haber, Daniel A. ^{[1
]}

Lynch, Thomas J. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, BioMEMS Resource Ctr, Boston, MA USA

来源：

JOURNAL OF THORACIC ONCOLOGY | 2009年 / 4卷 / 03期

关键词：

Circulating tumor cells; Non-small cell lung cancer; EGFR mutation; CTC-chip; METASTATIC BREAST-CANCER; ACQUIRED-RESISTANCE; EGFR MUTATIONS; PHASE-II; GEFITINIB; ERLOTINIB; THERAPY;

D O I：

10.1097/JTO.0b013e3181989565

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circulating tumor cells (CTCs) are rare cells that originate from a malignancy and circulate freely in the peripheral blood. The ability to capture and study CTCs is an emerging field with implications for early detection, diagnosis, determining prognosis and monitoring of cancer, as well as for understanding the fundamental biology of the process of metastasis, Here, we review the development and initial clinical studies with a novel microfluidic platform for isolating these cells, the CTC-chip, and discuss its potential uses in the study of lung cancer.

引用

页码：281 / 283

页数：3

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