Determination of remifentanil in human heparinised whole blood by tandem mass spectrometry with short-column separation

被引：39

作者：

Bender, J

van den Elshout, J

Selinger, K

Broeders, G

Dankers, J

van der Heiden, C

机构：

[1] Analyt Mednet BV, NL-4800 CD Breda, Netherlands

[2] Glaxo Wellcome Inc, Res Triangle Pk, NC 27709 USA

[3] Glaxo Wellcome BV, NL-3705 LZ Zeist, Netherlands

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1999年 / 21卷 / 03期

关键词：

remifentanil; liquid chromatography; mass spectrometry; LC-MS/MS; human blood;

D O I：

10.1016/S0731-7085(99)00151-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

For the use in pharmacokinetic studies, a fast and sensitive assay method was developed for the determination of remifentanil in human heparinised whole blood samples of 0.5 mi. The assay method is based on tandem mass spectrometry detection (LC-MS/MS). The limit of quantification is 0.1 ng/ml and linear up to 50 ng/ml. The precision, accuracy, recovery and applicability were found to be adequate for pharmacokinetic studies. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：559 / 567

页数：9

共 14 条

[1] Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat
Buerkle, H
Marsala, M
Yaksh, TL
[J]. BRITISH JOURNAL OF ANAESTHESIA, 1998, 80 (03) : 348 - 353
[2] Chism JP, 1996, DRUG METAB DISPOS, V24, P34
[3] THE PHARMACOKINETICS OF THE NEW SHORT-ACTING OPIOID REMIFENTANIL (GI87084B) IN HEALTHY ADULT MALE-VOLUNTEERS
EGAN, TD
LEMMENS, HJM
FISET, P
HERMANN, DJ
MUIR, KT
STANSKI, DR
SHAFER, SL
[J]. ANESTHESIOLOGY, 1993, 79 (05) : 881 - 892
[4] DETERMINATION OF REMIFENTANIL IN HUMAN BLOOD BY LIQUID-LIQUID-EXTRACTION AND CAPILLARY GC-HRMS-SIM USING A DEUTERATED INTERNAL STANDARD
GROSSE, CM
DAVIS, IM
ARRENDALE, RF
JERSEY, J
AMIN, J
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1994, 12 (02) : 195 - 203
[5] The pharmacokinetics and electroencephalogram response of remifentanil alone and in combination with esmolol in the rat
Haidar, SH
Moreton, JE
Liang, ZM
Hoke, JF
Muir, KT
Eddington, ND
[J]. PHARMACEUTICAL RESEARCH, 1997, 14 (12) : 1817 - 1823
[6] Determination of remifentanil, an ultra-short-acting opioid anesthetic, in rat blood by high performance liquid chromatography with ultraviolet detection
Haidar, SH
Liang, ZM
Selinger, K
Hamlett, L
Eddington, ND
[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1996, 14 (12) : 1727 - 1732
[7] Evaluating a possible pharmacokinetic interaction between remifentanil and esmolol in the rat
Haidar, SH
Moreton, JE
Liang, ZM
Hoke, JF
Muir, KT
Eddington, ND
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (11) : 1278 - 1282
[8] HAIDAR SH, 1995, PHARMACEUT RES, V12, P1120
[9] HAIDAR SH, 1996, P SOC EXP BIOL MED, V212, P386
[10] Remifentanil, an esterase-metabolised opioid - What advantages does it offer in analgesia and anaesthesia?
Lauwers, M
Camu, F
Vanlersberghe, C
[J]. CNS DRUGS, 1997, 8 (03) : 189 - 198

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