Premature ovarian failure (POF) in Brazilian fragile X carriers

被引：11

作者：

Vianna-Morgante, AM ^{[1
]}

Costa, SS ^{[1
]}

Pavanello, RDM ^{[1
]}

Otto, PA ^{[1
]}

Mingroni-Netto, RC ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biociencias, Dept Biol, BR-05422970 Sao Paulo, Brazil

来源：

GENETICS AND MOLECULAR BIOLOGY | 1999年 / 22卷 / 04期

关键词：

D O I：

10.1590/S1415-47571999000400002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gynecological and reproductive histories of 193 women from fragile X families were surveyed. Among the 101 carriers of the premutation, 14 experienced premature menopause, contrarily to their 37 fully mutated and 55 noncarrier female relatives. Although premature menopause showed a tendency to cluster in certain fragile X families, as a group, the premutated women experienced menopause earlier than noncarriers. This suggests that premature menopause may be the extreme effect of a spectrum of ovarian anomalies associated with the fragile X premutation.

引用

页码：471 / 474

页数：4

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