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Melatonin, its receptors, and relationships with biological rhythm disorders

被引：60
作者：
Delagrange, P
GuardiolaLemaitre, B
机构：
[1] Inst. de Rech. Intl. Servier, Courbevioe
[2] Servier Intl. Research Institute, 92415 Courbevoie Cedex
来源：
CLINICAL NEUROPHARMACOLOGY | 1997年 / 20卷 / 06期
关键词：
melatonin; humans; treatment; circadian rhythms;
D O I：
10.1097/00002826-199712000-00002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Melatonin is a neurohormone produced during the night by the pineal gland. Its secretion is regulated by circadian and seasonal variations in daylength, transmitted via visual projections to the suprachiasmatic nucleus which functions as a circadian clock in mammals. Melatonin has been proposed to act as an internal synchronizer of circadian rhythms generated at different levels of the organism. The chronobiotic effects of melatonin in humans have been mainly studied in circadian rhythm sleep disorders related to jet lag, shift work, blindness or aging. Alterations of the melatonin profiles have also been reported in other biological rhythm disorders.
引用
收藏
页码：482 / 510
页数：29
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