Multiple system atrophy (MSA):: Topographic distribution of the α-synuclein-associated pathological changes

被引：24

作者：

Armstrong, R. A. ^{[1
]}

Cairns, N. J.

Lantos, P. L.

机构：

[1] Aston Univ, Birmingham B4 7ET, W Midlands, England

[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63108 USA

[3] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63108 USA

[4] Washington Univ, Sch Med, Dept Immunol, St Louis, MO 63108 USA

[5] Kings Coll London, Inst Psychiat, Brain Bank, Dept Neuropathol, London SE5 8AF, England

来源：

PARKINSONISM & RELATED DISORDERS | 2006年 / 12卷 / 06期

关键词：

multiple system atrophy (MSA); glial cytoplasmic inclusion (GO); neuronal inclusion (NI); frontal cortex; basal ganglia; spatial patterns;

D O I：

10.1016/j.parkreldis.2006.02.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To study the topographic distribution of the pathology in multiple system atrophy (MSA). Pattern analysis was carried out using alpha-synuclein immunohistochemistry in 10 MSA cases. The glial cytoplasmic inclusions (GCI) were distributed randomly or in large clusters. The neuronal inclusions (NI) and abnormal neurons were distributed in regular clusters. Clusters of the NI and abnormal neurons were spatially correlated whereas the GCI were not spatially correlated with either the NI or the abnormal neurons. The data suggest that the GO represent the primary change in MSA and the neuronal pathology develops secondary to the glial pathology. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：356 / 362

页数：7

共 25 条

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Clustering of Pick bodies in patients with Pick's disease [J].