DNA hydrolysis by inorganic catalysts

被引：92

作者：

Ott, R ^{[1
]}

Krämer, R ^{[1
]}

机构：

[1] Univ Munster, Inst Anorgan Chem, D-48149 Munster, Germany

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 1999年 / 52卷 / 06期

关键词：

D O I：

10.1007/s002530051588

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Non-enzymatic reagents that efficiently promote the hydrolytic cleavage of DNA currently receive much attention since they have many potential applications in molecular biology. This review focuses on recent progress in the hydrolysis of the phosphodiester backbone of DNA by metal ions and metal complexes. Pioneering work on the sequence-selective DNA scission by an artificial restriction enzyme? which is prepared by covalent attachment of a cerium(IV) complex to an antisense-deoxyoligonucleotide, is discussed.

引用

页码：761 / 767

页数：7

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