Disease mechanism - Unravelling Wiskott-Aldrich syndrome

被引：44

作者：

Kirchhausen, T ^{[1
]}

Rosen, FS ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

来源：

CURRENT BIOLOGY | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/S0960-9822(09)00447-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.

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页码：676 / 678

页数：3

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