3-[123I]iodo-α-methyl-L-tyrosine:: uptake mechanisms and clinical applications

被引：60

作者：

Langen, KJ ^{[1
]}

Pauleit, D

Coenen, HH

机构：

[1] Forschungszentrum Julich, Res Ctr, Inst Med, D-5170 Julich, Germany

[2] Univ Dusseldorf, Clin Nucl Med, D-4000 Dusseldorf, Germany

[3] Forschungszentrum Julich, Res Ctr, Inst Nucl Chem, D-5170 Julich, Germany

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2002年 / 29卷 / 06期

关键词：

3-[I-123]iodo-alpha-methyl-L-tyrosine; amino acid transport; tumors; SPECT;

D O I：

10.1016/S0969-8051(02)00328-1

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

3-[I-123]Iodo-alpha-methyl-L-tyrosine (IMT) is an artificial amino acid which has gained considerable interest in Nuclear Medicine in the last two decades. Although the tracer is not incorporated into proteins it exhibits high uptake in brain tumors and appears to be a valuable tool especially for the diagnostic evaluation and therapy planning of patients with cerebral gliomas. In this paper the present knowledge of the uptake mechanisms and the clinical applications of IMT are reviewed and the clinical perspectives discussed. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：625 / 631

页数：7

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