Role of ceramide in suramin-induced cancer cell death

被引：17

作者：

Gill, JS ^{[1
]}

Windebank, AJ ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,MAYO CANC CTR,ROCHESTER,MN 55905

来源：

CANCER LETTERS | 1997年 / 119卷 / 02期

关键词：

breast; prostate; PC12; apoptosis; BODIPY ceramide;

D O I：

10.1016/S0304-3835(97)00272-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. Recent in vitro studies from our laboratory report a disruption in glycolipid metabolism and cell death in suramin-treated neurons. Evidence presented in this study proposes to consolidate the neurotoxic and cytotoxic effects of suramin. Electron microscopic studies, bis-benzimide staining and DNA gel electrophoresis of suramin and C-2-ceramide treatment revealed apoptotic cells in human breast, prostate and rat neuron like cell lines. Apoptotic cell death was preceded by an elevation in intracellular ceramide. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：169 / 176

页数：8

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