Clinical implication of expression of vascular endothelial growth factor-C in metastatic lymph nodes of uterine cervical cancers

被引：36

作者：

Fujimoto, J ^{[1
]}

Toyoki, H ^{[1
]}

Sato, E ^{[1
]}

Sakaguchi, H ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5011193, Japan

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 03期

关键词：

VEGF-C; metastatic lymph node; prognosis; uterine cervical cancer;

D O I：

10.1038/sj.bjc.6601963

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial cell growth factor (VEGF)-C levels were significantly (P < 0.05) increased in 24 out of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the 24 patients with increased VEGF-C level in metastatic lymph node lesions was poor and the 24-month survival rate was 38%, while the rate of the 16 patients with no change in VEGF-C level in metastatic lymph node lesions was 81%. There was a significant (P < 0.01) difference in the 24-month survival rates between the two groups. This is novel, direct evidence that VEGF-C might contribute to the aggressive lymphangitic metastasis in uterine cervical cancers, and that the increase in VEGF-C level from primary tumour to metastatic lymph node might be a prognostic indicator.

引用

页码：466 / 469

页数：4

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