Quantitating therapeutic disruption of tumor blood flow with intravital video microscopy

被引：9

作者：

Iga, Arthur M.

Sarkar, Sandip

Sales, Kevin M.

Winslet, Marc C.

Seifalian, Alexander M.

机构：

[1] UCL, Acad Div Surg & Intervent Sci, GI & Hepatobiliary Res Unit, London NW3 2PF, England

[2] Royal Free Hampstead NHS Trust Hosp, Dept Surg, London, England

来源：

CANCER RESEARCH | 2006年 / 66卷 / 24期

关键词：

D O I：

10.1158/0008-5472.CAN-06-1743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular-disrupting agents (VDA) kill tumor cells by selectively disrupting blood circulation in tumors. In vivo analysis of this intensely studied class of anticancer agents is invaluable for preclinical assessment of pharmacodynamic end points and effective therapeutic windows. In this review, we consider the role of intravital video microscopy in measuring tumor vascular response to VDAs, the potential of which lies in the opportunity to quantitate specific variables and to obtain real-time information on how VDAs affect tumor microcirculation.

引用

收藏

页码：11517 / 11519

页数：3

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