Regulation of life and death by the zinc finger transcription factor Egr-1

被引：516

作者：

Thiel, G ^{[1
]}

Cibelli, G

机构：

[1] Univ Saarland, Med Ctr, Dept Med Biochem & Mol Biol, D-66421 Homburg, Germany

[2] Univ Foggia, Fac Med, Dept Biomed Sci, Foggia, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2002年 / 193卷 / 03期

关键词：

D O I：

10.1002/jcp.10178

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The biosynthesis of the zinc finger transcription factor Egr-1 is stimulated by many extracellular signaling molecules including hormones, neurotransmitters, growth and differentiation factors, and cytotoxic metabolites. The 5'-flanking region of the Egr-1 gene contains genetic elements that are essential in connecting stimulation of the cells with enhanced transcription of the Egr-1 gene, and subsequently, transcription of Egr-1-responsive genes. Thus, Egr-1 links cellular signaling cascades with changes in the gene expression pattern. Many biological functions have been attributed to Egr-1. Here, we discuss evidence for Egr-1 control of cellular proliferation and programmed cell death.

引用

页码：287 / 292

页数：6

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