Palmerolide A, a cytotoxic macrolide from the Antarctic tunicate Synoicum adareanum

被引：128

作者：

Diyabalanage, T

Amsler, CD

McClintock, JB

Baker, BJ

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ Alabama Birmingham, Dept Biol, Birmingham, AL 35294 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 17期

关键词：

D O I：

10.1021/ja0588508

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 μM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase. Copyright © 2006 American Chemical Society.

引用

页码：5630 / 5631

页数：2

共 6 条

[1]

Amsler CD, 2001, CRC MAR SCI, P267

[2]

DAYTON PK, 1994, AM ZOOL, V34, P90

[3]

KURZ M, 1991, ANGEW CHEM INT EDIT, V30, P1329, DOI 10.1002/anie.199113291

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