Potential role of fluoroquinolone therapy in childhood otitis media

被引：15

作者：

Dagan, R

Arguedas, A

Schaad, UB

机构：

[1] Ben Gurion Univ Negev, Soroka Univ, Med Ctr, Pediat Infect Dis Unit, IL-84101 Beer Sheva, Israel

[2] Inst Atenc Pediat, San Jose, Costa Rica

[3] Univ Autonoma Ciencias Med, San Jose, Costa Rica

[4] Univ Childrens Hosp, Div Pediat Infect Dis, Basel, Switzerland

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2004年 / 23卷 / 05期

关键词：

fluoroquinolones; pediatrics; otitis media; antimicrobial resistance; gatifloxacin;

D O I：

10.1097/01.inf.0000126272.08795.7a

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increased resistance of pneumococci and other pathogens to available antibiotics raises concerns about bacteriologic and clinical failure in children with acute otitis media. Few therapeutic options exist for patients with recurrent infections or recent treatment failure. The limited experience from the compassionate use of fluoroquinolones in pediatrics and pediatric studies has not been linked unequivocally with arthrotoxicity, the primary safety concern in children. Newer 8-methoxyfluoroquinolones may have a role in selected cases associated with multidrug-resistant pathogens.

引用

收藏

页码：390 / 398

页数：9

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