Thrombotic arteriopathy and anticoagulation in pulmonary hypertension

被引：116

作者：

Johnson, Sindhu R.

Granton, John T.

Mehta, Sanjay

机构：

[1] Univ Toronto, Univ Hlth Network, Div Rheumatol, Toronto, ON, Canada

[2] Univ Toronto, Univ Hlth Network, Pulm Hypertens Ctr, Toronto, ON, Canada

[3] London Hlth Sci Ctr, Div Respirol, Lawson Hlth Res Inst, Ctr Crit Illness Res, London, ON, Canada

来源：

CHEST | 2006年 / 130卷 / 02期

关键词：

idiopathic pulmonary arterial hypertension; pulmonary hypertension; thrombosis; thrombotic arteriopathy;

D O I：

10.1016/S0012-3692(15)51873-4

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The role of thrombotic arteriopathy in the pathophysiology of idiopathic pulmonary arterial hypertension (IPAH) and the use of anticoagulants in the treatment of IPAH are currently controversial issues. This article reviews the evidence for a role of vascular thrombosis in the pathophysiology of IPAH. There is sufficient biological rationale to support the notion that thrombotic arteriopathy is an important pathophysiologic feature of pulmonary arterial hypertension (PAH) and that its progression materially contributes to disease progression. To date, the data from observational studies suggest that anticoagulation with warfarin is an effective intervention in patients with IPAH. Its efficacy in other causes of PAH remains speculative.

引用

收藏

页码：545 / 552

页数：8

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