Delivery of endocytosed membrane proteins to the lysosome

被引：103

作者：

Pryor, Paul R. ^{[1
]}

Luzio, J. Paul ^{[2
,3
]}

机构：

[1] Univ York, Dept Biol, Aera 9, York YO10 5YW, N Yorkshire, England

[2] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 0XY, England

[3] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 0XY, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2009年 / 1793卷 / 04期

基金：

英国惠康基金;

关键词：

Endocytosis; Late endosomes; Lysosomes; Multivesicular body; Membrane fusion; MUCOLIPIDOSIS TYPE-IV; HOMOTYPIC VACUOLE FUSION; ADENINE-DINUCLEOTIDE PHOSPHATE; MULTIVESICULAR BODY FORMATION; N-TERMINAL DOMAIN; CELL-FREE ASSAY; C VPS COMPLEX; ESCRT-III; LATE ENDOSOMES; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/j.bbamcr.2008.12.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The delivery of proteins from the plasma membrane to the lysosome for degradation is essential for normal cellular function. There is now a good understanding of the protein complexes involved in sorting proteins at the plasma membrane and into the intralumenal vesicles of the multi-vesicular body. A combination of cell free content mixing assays and live-cell imaging has dissected out the final step in delivery of macromolecules to the lysosome from the multi-vesicular body and provided insights into the molecular mechanisms by which late endosomes and lysosomes exchange lumenal contents. The endocytic pathway has provided a platform with which to understand the autophagic and phagocytic pathways, but the fine details of how traffic through these pathways is regulated remain to be determined. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：615 / 624

页数：10

共 124 条

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[2]

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