Synthesis and structure activity relationship of guanidines as NPYY5 antagonists

被引：13

作者：

Aquino, CJ ^{[1
]}

Ramanjulu, JM

Heyer, D

Daniels, AJ

Palazzo, F

Dezube, M

机构：

[1] RTP, GlaxoSmithKline, Dept Med Chem, Res Triangle Pk, NC 27709 USA

[2] GlaxoSmithKline, Dept Chem, Collegeville, PA 19426 USA

[3] RTP, GlaxoSmithKline, Dept Metab Dis, Res Triangle Pk, NC 27709 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 10期

关键词：

D O I：

10.1016/j.bmc.2004.03.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2691 / 2708

页数：18

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