Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD

被引：60

作者：

van der Flier, WM

Middelkoop, HAM

Weverling-Rijnsburger, AWE

Admiraal-Behloul, F

Spilt, A

Bollen, ELEM

Westendorp, RGJ

van Buchem, MA

机构：

[1] Leiden Univ, Med Ctr, Dept Neurol J3R, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Gen Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Dept Radiol, Sect Image Proc, Leiden, Netherlands

来源：

NEUROLOGY | 2004年 / 62卷 / 10期

关键词：

D O I：

10.1212/01.WNL.0000125337.65553.8A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated the interaction between medial temporal lobe (MTL) atrophy and white matter hyperintensities (WMH) in Alzheimer disease (AD). They measured the MTL and WMH on MRI in 58 AD patients and 28 controls. MTL atrophy was associated with an increased risk of AD (OR = 6.2), but there was no significant association between WMH and AD. Moreover, there was an interaction between MTL and WMH ( p = 0.045). These results suggest that vascular and Alzheimer-type pathology act in synergy in the clinical syndrome of AD.

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页码：1862 / 1864

页数：3

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