Induction of apoptosis in a Drosophila neuronal cell line by calcium ionophore

被引：11

作者：

UiTei, K

Sato, S

Miyake, T

Miyata, Y

机构：

[1] NIPPON MED COLL, DEPT PHARMACOL, BUNKYO KU, TOKYO 113, JAPAN

[2] NIPPON MED COLL, CENT INST ELECTRON MICROSCOP RES, BUNKYO KU, TOKYO 113, JAPAN

[3] MITSUBISHI KASEI INST LIFE SCI, DIV PIONEERING RES, MACHIDA, TOKYO 194, JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 203卷 / 03期

关键词：

Drosophila; CNS cell line; DNA fragmentation; Ca2+; apoptosis;

D O I：

10.1016/0304-3940(95)12292-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptotic type cell death was induced by the calcium ionophore, A23187, in a Drosophila CNS derived cell line, ML-DmBG2-c2. It was judged by the ultrastructural observations and internucleosomal DNA fragmentation, typical characteristics of apoptosis. The ionophore failed to induce apoptosis in Ca2+- free medium, which suggests that the increase of intracellular Ca2+ concentration by the treatment of A23187 triggers apoptosis in the clonal cells.

引用

页码：191 / 194

页数：4

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