A note on testing areas under the curve when using destructive measurement techniques

被引:12
作者
Heinzl, H
机构
[1] Dept. of Medical Computer Sciences, University of Vienna, A-1090 Vienna
来源
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1996年 / 24卷 / 06期
关键词
destructive sampling; Welch's test;
D O I
10.1007/BF02353485
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The area under the curve of drug concentration over time is considered important in many toxicological, pharmacological, and medical investigations. In case that only one measurement for each experimental unit has been recorded, the area under the cur ve has to be estimated on the basis of the mean concentration values at the measurement times. Defining an estimator by using a linear combination of these mean values enables the straightforward estimation of the corresponding variance. For testing the null hypothesis of equality between two areas under the curve the use of Welch's test for nonpairwise contrasts is recommended; the previously suggested normal approximation of the test statistic is not an adequate choice since it exceeds the nominal a-level, this is illustrated by simulation studies.
引用
收藏
页码:651 / 655
页数:5
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