Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

被引：403

作者：

Li, Yanping ^{[1
]}

Liu, Wencheng ^{[1
]}

Oo, Tinmarla F. ^{[2
,3
]}

Wang, Lei ^{[1
,4
]}

Tang, Yi ^{[1
]}

Jackson-Lewis, Vernice ^{[2
,3
]}

Zhou, Chun ^{[2
,3
]}

Geghman, Kindiya ^{[1
]}

Bogdanov, Mikhail ^{[1
,4
]}

Przedborski, Serge ^{[2
,3
]}

Beal, M. Flint ^{[1
]}

Burke, Robert E. ^{[2
,3
]}

Li, Chenjian ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, New York, NY 10021 USA

[2] Columbia Univ, Dept Neurol, New York, NY USA

[3] Columbia Univ, Dept Pathol, New York, NY USA

[4] Bedford Vet Adm Med Ctr, Bedford, MA USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 07期

基金：

美国国家卫生研究院;

关键词：

MUTATION; GENE; ACTIVATION; EXPRESSION; PATHOLOGY; REGION;

D O I：

10.1038/nn.2349

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutics.

引用

页码：826 / 828

页数：3

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