Evidence for complement activation in ruptured coronary plaques in acute myocardial infarction

被引：60

作者：

Laine, P

Pentikäinen, MO

Würzner, R

Penttilä, A

Paavonen, T

Meri, S

Kovanen, PT

机构：

[1] Wihuri Res Inst, FIN-00140 Helsinki, Finland

[2] Univ Innsbruck, Inst Hyg & Social Med, A-6020 Innsbruck, Austria

[3] Univ Helsinki, Dept Forens Med, SF-00300 Helsinki, Finland

[4] Univ Helsinki, Dept Pathol, Helsinki, Finland

[5] Univ Helsinki, Dept Bacteriol & Immunol, Helsinki, Finland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2002年 / 90卷 / 04期

基金：

芬兰科学院;

关键词：

D O I：

10.1016/S0002-9149(02)02498-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We found extensive deposition of complement iC3b in ruptured, but not in nonruptured, atherosclerotic plaques from infarct-related human coronary arteries. Complement activation could aggravate inflammation at the site of plaque rupture by stimulating inflammatory cells, and thus influence plaque stability and remodeling.

引用

收藏

页码：404 / +

页数：6

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