Prevalence of Helicobacter pylori infection in asymptomatic subjects in Libya

Helicobacter pylori infection is very common infection worldwide particularly in the developing countries. No detailed study on such infection is being recorded so far in Libya. The aims of the study were to detect H. pylori prevalence in asymptomatic Libyan subjects, to determine the rate of infection among different age groups and to correlate the prevalence of H. pylori with age, sex, smoking, non-steroidal anti-inflammatory drugs intake, marital status, education, and socioeconomic status. Three hundred and sixty asymptomatic subjects 1->70 years of age (average 36) with no previous history of epigastric pain were selected randomly from the Libyan population. Serum samples were obtained and a questionnaire was filled for each subject. The ELISA test was used to detect IgG anti-H. pylori antibodies. An overall prevalence of 76% was detected in these subjects. A 50% infection rate were in subjects 1-9 years of age that increased to 84% in subjects 10-19 years and continued with increasing age and reached up to 94% in those over 70 years of age. Subjects >45 years of age had significantly higher antibody response than those <45 years. H. pylori prevalence was higher in married subjects (84%) as compared to singles (68%) and similarly in illiterates (89%) and low socioeconomic subjects (91%). No difference in sex, smoking and NSAIDs intake was recorded. Infection with H. pylori is highly prevalent in the Libyan asymptomatic subjects. Infection acquired early in childhood and reached up to 94% in older age. Prevalence of H. pylori was significantly increased in association with marital status, education and low socioeconomic status. (C) 2002 Elsevier Science Inc. All rights reserved.