Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma

被引:82
作者
Giannini, Edoardo Giovanni
Risso, Domenico
Testa, Roberto
Trevisani, Franco
Di Nolfo, Maria Anna
Del Poggio, Paolo
Benvegnu, Luisa
Rapaccini, Gian Ludovico
Farinati, Fabio
Zoli, Marco
Borzio, Franco
Caturelli, Eugenio
机构
[1] Univ Genoa, Dept Internal Med, Gastroenterol Unit, Cattedra Gastroenterol, I-16132 Genoa, Italy
[2] Univ Bologna, Alma Mater Studiorum, Dipartimento Med Interna Cardioangiol Epatol, Bologna, Italy
[3] Osped Treviglio Caravaggio, Div Med, Treviglio, Italy
[4] Osped Bolognini, Div Med, Seriate, Italy
[5] Univ Padua, Dipartimento Med Clin & Sperimentale, Padua, Italy
[6] Univ Padua, Dipartimento Sci Chirurg & Gastroenterol, Padua, Italy
[7] Univ Cattolica Roma, Cattedra Med Interna 2, Rome, Italy
[8] Osped Fatebenefratelli, Dipartimento Med, Unita Gastroenterol, Milan, Italy
[9] Osped Belcolle, Unita Gastroenterol, Viterbo, Italy
关键词
D O I
10.1016/j.cgh.2006.08.011
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: It has been suggested that clinically relevant portal hypertension may affect the therapeutic management and prognosis of cirrhotic patients with hepatocellular carcinoma (HCC). Nevertheless, the importance of the presence of esophageal varices in these patients has not yet been addressed formally. in this study our aim was to evaluate the prevalence and prognostic relevance of the presence of esophageal varices in a large series of patients with HCC. Methods: The prevalence of esophageal varices was evaluated in 1153 HCC patients who were consecutively referred to 10 Italian centers (the Italian Liver Cancer group). Survival was calculated from the time of HCC diagnosis until death or until the most recent follow-up visit, and was evaluated according to the presence or absence of esophageal varices. The independent prognostic meaning of the presence of esophageal varices was evaluated further in a multivariate regression analysis. Results: Esophageal varices were found in 730 patients (63.3%). Patients with varices showed significantly shorter survival times (P <.0001) as compared with patients without varices. Death as a result of bleeding was more common in patients with varices (P =.0127). In multivariate analysis, the presence of esophageal varices was associated independently with poorer survival (adjusted relative risk, 1.25; 95% confidence interval, 1.06-1.48; P = .0095). Conclusions: More than half of the patients with HCC have esophageal varices. The presence of esophageal varices is associated with a higher risk of death from bleeding, and is an independent determinant of the patient's prognosis. This variable should be taken into account in the diagnostic and therapeutic work-up of HCC patients.
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页码:1378 / 1384
页数:7
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