Evaluation of calorimetric and gravimetric methods to quantify the amorphous content of desferal

被引：17

作者：

Fiebich, K ^{[1
]}

Mutz, M

机构：

[1] Novartis Pharma AG, Pharmaceut & Analyt Dev, CH-4002 Basel, Switzerland

[2] Novartis Pharma AG, Chem & Analyt Dev, CH-4002 Basel, Switzerland

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 1999年 / 57卷 / 01期

关键词：

amorphous phases; Desferal; gravimetry; isothermal microcalorimetry; recrystallization; relative humidity; water vapor sorption;

D O I：

10.1023/A:1010153401365

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The amorphous content of different Desferal samples was quantified by recording its recrystallization using isothermal microcalorimetry in a static as well as in a flowing humid atmosphere. Furthermore water vapor sorption gravimetry was performed for the same purpose. These analytical methods result in a quantitative signal directly dependent on the content of the amorphous phase (recrystallization, water sorption equilibrium). Their sensitivity allows the detection of amorphous content below 1%. Methods are compared and advantages and disadvantages are discussed.

引用

页码：75 / 85

页数：11

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