Treatment of Metastatic Melanoma with Electrochemotherapy

被引:40
作者
Campana, Luca G. [1 ]
Testori, Alessandro [2 ]
Mozzillo, Nicola [3 ]
Rossi, Carlo Riccardo [1 ]
机构
[1] Ist Oncol Veneto IOV IRCCS, Padua, Italy
[2] Ist Europeo Oncol IEO IRCCS, Milan, Italy
[3] Fdn G Pascale IRCCS, Ist Nazl Studio & Cura Tumori, Naples, Italy
关键词
melanoma; locoregional therapies; palliative therapy; electrochemotherapy; bleomycin; STANDARD OPERATING PROCEDURES; IN-TRANSIT MELANOMA; ANTITUMOR EFFECTIVENESS; MALIGNANT-MELANOMA; ELECTRIC PULSES; CUTANEOUS METASTASES; INTRALESIONAL BLEOMYCIN; SUBCUTANEOUS TUMORS; CLINICAL-EXPERIENCE; SKIN METASTASES;
D O I
10.1002/jso.23512
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Superficially metastatic melanoma still represents a challenging situation for oncologists and a distressing condition for patients. In this circumstance, local treatment by electrochemotherapy, that is, the combination of brief permeabilizing electric pulses with a low-toxicity anticancer drug, can be a valuable treatment option in selected patients who are ineligible/refractory to systemic treatments or require rapid palliation of symptomatic cutaneous disease. J. Surg. Oncol. 2014 109:301-307. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:301 / 307
页数:7
相关论文
共 58 条
[1]
Role of electrochemotherapy in the treatment of metastatic melanoma and other metastatic and primary skin tumors [J].
Byrne, Christopher M. ;
Thompson, John F. .
EXPERT REVIEW OF ANTICANCER THERAPY, 2006, 6 (05) :671-678
[2]
Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy) [J].
Byrne, CM ;
Thompson, JF ;
Johnston, H ;
Hersey, P ;
Quinn, MJ ;
Hughes, TM ;
McCarthy, WH .
MELANOMA RESEARCH, 2005, 15 (01) :45-51
[3]
Electrochemotherapy for disseminated superficial metastases from malignant melanoma [J].
Campana, L. G. ;
Valpione, S. ;
Mocellin, S. ;
Sundararajan, R. ;
Granziera, E. ;
Sartore, L. ;
Chiarion-Sileni, V. ;
Rossi, C. R. .
BRITISH JOURNAL OF SURGERY, 2012, 99 (06) :821-830
[4]
Bleomycin-Based Electrochemotherapy: Clinical Outcome from a Single Institution's Experience with 52 Patients [J].
Campana, Luca G. ;
Mocellin, Simone ;
Basso, Michela ;
Puccetti, Oliviero ;
De Salvo, Gian Luca ;
Chiarion-Sileni, Vanna ;
Vecchiato, Antonella ;
Corti, Luigi ;
Rossi, Carlo R. ;
Nitti, Donato .
ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (01) :191-199
[5]
Electroporation of human microvascular endothelial cells: evidence for an anti-vascular mechanism of electrochemotherapy [J].
Cemazar, M ;
Parkins, CS ;
Holder, AL ;
Chaplin, DJ ;
Tozer, GM ;
Sersa, G .
BRITISH JOURNAL OF CANCER, 2001, 84 (04) :565-570
[6]
Modeling of electric field distribution in tissues during electroporation [J].
Corovic, Selma ;
Lackovic, Igor ;
Sustaric, Primoz ;
Sustar, Tomaz ;
Rodic, Tomaz ;
Miklavcic, Damijan .
BIOMEDICAL ENGINEERING ONLINE, 2013, 12
[7]
Randomized controlled study of electrochemotherapy in the local treatment of skin metastases of melanoma [J].
Gaudy, Cardine ;
Richard, Marie-Aleth ;
Folchetti, Gilles ;
Bonerandi, Jean Jacques ;
Grob, Jean-Jacques .
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2006, 10 (03) :115-121
[8]
Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research [J].
Gehl, J .
ACTA PHYSIOLOGICA SCANDINAVICA, 2003, 177 (04) :437-447
[9]
Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy [J].
Gehl, J ;
Geertsen, PF .
MELANOMA RESEARCH, 2000, 10 (06) :585-589
[10]
Enhancing anti-melanoma immunity by electrochemotherapy and in vivo dendritic-cell activation [J].
Gerlini, Gianni ;
Di Gennaro, Paola ;
Borgognoni, Lorenzo .
ONCOIMMUNOLOGY, 2012, 1 (09) :1655-1657