A developmental examination of gender differences in brain engagement during evaluation of threat

被引:178
作者
McClure, EB
Monk, CS
Nelson, EE
Zarahn, E
Leibenluft, E
Bilder, RM
Charney, DS
Ernst, M
Pine, DS
机构
[1] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
[2] Columbia Univ, Dept Psychiat, New York, NY USA
[3] NIMH, Mood & Anxiety Disorders Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
[4] NIMH, Sect Dev & Affect Neurosci, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA
[5] NIMH, Mood & Anxiety Disorders Program, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
关键词
gender; development; fMRI; facial expression; emotion; threat;
D O I
10.1016/j.biopsych.2004.02.013
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Females appear to be more sensitive and responsive to social cues, including threat signals, than are males. Recent theoretical models suggest that developmental changes in brain functioning play important roles in the emergence of such gender differences. Methods: We used functional magnetic resonance imaging to examine developmental and gender differences in activation of neural structures thought to mediate attention to emotional faces depicting varying degrees of threat. Analyses focused on the orbitofrontal cortex, amygdala, and anterior cingulate cortex during the evaluation of threat conveyed by faces. Healthy adolescents (n = 17.53% male) and adults (n = 17; 53% male) were scanned while they rated how threatening pictures of neutral and emotional (angry, fearful, or happy) faces appeared. Results: Results indicate significant interactions among aged, gender, and,face type for activation during explicit threat monitoring. In particular adult women activated orbitofrontal cortex and amygdala selectively to unambiguous threat (angry) cues, while adult men showed a less discriminating pattern of activation. No gender differences were evident for adolescents, who as a group resembled adult males. Conclusions: These findings suggest that there are gender differences in patterns of neural responses to emotional laces that are not fully apparent until adulthood.
引用
收藏
页码:1047 / 1055
页数:9
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