Total intracranial volume: Normative values and lack of association with Alzheimer's disease

被引：76

作者：

Edland, SD

Xu, Y

Plevak, M

O'Brien, P

Tangalos, EG

Petersen, RC

Jack, CR

机构：

[1] Mayo Clin & Mayo Fdn, Dept Hlth Sci Res, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA

[4] Mayo Clin & Mayo Fdn, Dept Radiol, Rochester, MN 55905 USA

来源：

NEUROLOGY | 2002年 / 59卷 / 02期

关键词：

D O I：

10.1212/WNL.59.2.272

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A larger premorbid brain is hypothesized to provide neuronal reserve against AD. Using MRI data from ongoing studies of normal aging and AD, the authors tested this hypothesis. Mean total intracranial volume was 15.8 cm(3) smaller for cases among women (n = 121 normal and 104 AD; p = 0.24) and 10.1 cm(3) larger for cases among men (n = 63 normal and 62 AD; p = 0.59). These differences are small and nonsignificant, suggesting that head size per se is not a critical determinant of AD.

引用

页码：272 / 274

页数：3

共 9 条

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