Characterization of a novel porin involved in systemic Yersinia enterocolitica infection

被引：12

作者：

Mildiner-Earley, Shirly

Miller, Virginia L.

机构：

[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 07期

关键词：

D O I：

10.1128/IAI.00154-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Yersinia enterocolitica is an enteric pathogen capable of causing systemic disease in a murine model. We have identified a novel protein, systemic factor protein A (SfpA), conserved in other pathogenic bacteria that is involved in systemic disease. Analysis of bacterial colonization revealed that a Delta sfpA strain is defective in mesenteric lymph node colonization. Bioinformatics and functional studies suggest that SfpA is a porin.

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收藏

页码：4361 / 4365

页数：5

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