High genetic diversity and poor in vitro response to antifungals of clinical strains of Fusarium oxysporum

被引：19

作者：

Azor, Monica ^{[1
]}

Cano, Josep ^{[1
]}

Gene, Josepa ^{[1
]}

Guarro, Josep ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Fac Med & Ciencies Salut, IISPV, Unitat Microbiol,Med Sch, E-43201 Reus, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2009年 / 63卷 / 06期

关键词：

Fusarium; molecular identification; elongation factor 1 alpha gene; antifungal susceptibility; SOLANI SPECIES COMPLEX; MOLECULAR PHYLOGENY;

D O I：

10.1093/jac/dkp095

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The aim of this study was to determine the genetic variability of clinical isolates morphologically identified as Fusarium oxysporum and to assess if there are differences in antifungal susceptibility among the possible genetic clades obtained. Twenty-eight isolates were molecularly characterized by sequence analysis of the elongation factor 1 alpha gene. The antifungal susceptibilities of these isolates to 11 antifungal drugs were tested using a microdilution method. We obtained four different phylogenetic clades in the molecular study. Although all the antifungals tested showed poor activity against all the genetic clades, terbinafine showed the best results.

引用

页码：1152 / 1155

页数：4

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