A CLOCK-less clock

被引：36

作者：

Asher, Gad ^{[1
]}

Schibler, Ueli ^{[1
]}

机构：

[1] Univ Geneva, Dept Biol Mol, CH-1211 Geneva 4, Switzerland

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 11期

关键词：

D O I：

10.1016/j.tcb.2006.09.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian physiology is governed by a complex circadian timing system that involves interacting positive and negative transcriptional feedback loops. A key role in this feedback loop was attributed to the PAS domain helix-loop-helix protein CLOCK, on the basis of a dominant-negative mutation in this transcription factor. However, recent experiments by Reppert and coworkers with Clock knockout mice suggest that CLOCK is dispensable for rhythmic gene expression and behavior, presumably because other proteins can substitute for CLOCK in these animals.

引用

页码：547 / 549

页数：3

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