Gene therapy for autoimmune diseases:: Quo Vadis?

被引：38

作者：

Chernajovsky, Y

Gould, DJ

Podhajcer, OL

机构：

[1] Univ London, Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Bone & Joint Res Unit, London EC1M 6BQ, England

[2] Univ Buenos Aires, Fac Exact & Nat Sci, CONICET, Inst Leloir, Buenos Aires, DF, Argentina

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri1459

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Biological therapies using antibodies and cytokines are becoming widespread for the treatment of chronic inflammatory autoimmune diseases. However, these treatments have several limitations - such as expense, the need for repeated injections and unwanted side-effects - that can be overcome by genetic delivery. This review summarizes the ingenuity, sophistication and variety of gene-therapy approaches that have been taken in the design of therapeutic molecules and vectors, the engineering of cells and the regulation of gene expression for the targeting of disease outcome. We focus our attention on multiple sclerosis, type 1 diabetes and rheumatoid arthritis.

引用

页码：800 / 811

页数：12

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