Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

被引：139

作者：

Aitipamula, Srinivasulu ^{[1
]}

Chow, Pui Shan ^{[1
]}

Tan, Reginald B. H. ^{[1
,2
]}

机构：

[1] ASTAR, Inst Chem & Engn Sci, Singapore 627833, Singapore

[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

来源：

CRYSTENGCOMM | 2009年 / 11卷 / 09期

关键词：

CO-CRYSTAL; 2,5-DIHYDROXYBENZOIC ACID; GENTISIC ACID; SOLVENT; POLYMORPH; CARBAMAZEPINE; TRANSFORMATION; ETHENZAMIDE; DISSOLUTION; IMPROVE;

D O I：

10.1039/b904616j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first example of a trimorphic cocrystal involving two active pharmaceutical ingredients (APIs), ethenzamide and gentisic acid, is reported; metastable polymorphs convert to the stable form upon solid-state grinding; pharmaceutical cocrystals involving two or more APIs have potential relevance to combination drugs.

引用

页码：1823 / 1827

页数：5

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