Genetic subtypes of HIV type 1 in Republic of Congo

被引:36
作者
Bikandou, B
Takehisa, J [1 ]
Mboudjeka, I
Ido, E
Kuwata, T
Miyazaki, Y
Moriyama, H
Harada, Y
Taniguchi, Y
Ichimura, H
Ikeda, M
Ndolo, PJ
Nzoukoudi, MY
M'Vouenze, R
M'Pandi, M
Parra, HJ
M'Pelé, P
Hayami, M
机构
[1] Kyoto Univ, Inst Virus Res, Lab Viral Pathogenesis, Sakyo Ku, Kyoto 6068507, Japan
[2] Cite Louis Pasteur Lab Natl Sante Publ, Brazzaville 120, Rep Congo
[3] Kanazawa Univ, Fac Med, Dept Int Environm Hlth, Kanazawa, Ishikawa 9208640, Japan
[4] Fujirebio Inc, Chuo Ku, Tokyo 1030007, Japan
[5] Ctr Hosp & Univ Brazzaville, Ctr Traitement Ambulatoire, Brazzaville 120, Rep Congo
关键词
D O I
10.1089/088922200308837
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To assess the molecular epidemiology of HIV-1 in Republic of Congo (Congo), we investigated 29 HIV-1s obtained from 82 Congolese AIDS and ARC patients in 1996 and 1997, Part of the env region including the V3 loop was phylogenetically analyzed. The genotypes observed were varied: of 29 specimens, 12 (41%) were subtype A, 1 (3%) was subtype D, 6 (21%) were subtype G, 6 (21%) were subtype H, 2 (7%) were subtype J, and 2 (7%) could not be classified as any known subtypes (U, unclassified), The heterogeneous profile of HIV-1 infection was different from the profiles of neighboring Central African countries. These data show that subtypes G and H as well as subtype A mere circulating with high prevalence. The fact that new genetic subtypes (J and U) are circulating indicates a need for a greater surveillance for these subtypes both in Congo as well as in other parts of the world.
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收藏
页码:613 / 619
页数:7
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